Pronounced: Per-nish-us Ah-nee-mee-ahEn Español (Spanish Version)
Anemia is a low level of healthy red blood cells (RBC). RBCs carry oxygen from the lungs to the rest of the body. When red blood cells are low the body does not get enough oxygen. This can cause symptoms such as fatigue, pale skin, or irregular heartbeat.
Pernicious anemia is associated with problems absorbing vitamin B12. This vitamin is needed to make healthy RBCs. Over time the low vitamin B12 levels will reduce the number of new RBCs. The sooner pernicious anemia is treated, the better the outcome.
Red Blood Cells
Copyright © Nucleus Medical Media, Inc.
There are many possible causes of pernicious anemia. These include:
- Inflammation of the stomach—atrophic gastritis
Immune system reaction to:
- Intrinsic factor—a protein necessary for vitamin B12 absorption
- Cells that produce both intrinsic factor and hydrochloric acid in the stomach
- Removal of all or part of the stomach
- Genetic defect
Last reviewedAugust 2014by Marcin Chwistek, MD
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.