Leukodystrophy is a break down of a component of the nervous system called the myelin, which is a significant part of what makes the white matter of the brain. Myelin protects the part of the nerve that sends signals throughout the brain. The break down of myelin makes it difficult for the brain to send these signals. Leukodystrophy is a rare disease.

Types of leukodystrophies include:

  • Metachromatic leukodystrophy
  • Krabbé disease
  • Adrenoleukodystrophy
  • Adrenomyelopathy
  • Pelizaeus-Merzbacher disease
  • Canavan disease
  • Childhood ataxia with central nervous system hypomyelination (CACH), which is also called vanishing white matter disease
  • Alexander disease
  • Refsum disease
  • Cerebrotendinous xanthomatosis

Most leukodystrophies begin in infancy or childhood. However, there are several types that may not begin until adolescence or early adulthood.

Neuronal Axon With Myelin Sheath
AX00010_97870_1_myelin_sheath
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Leukodystrophy is caused by a genetic defect. This defect impairs the growth or development of the myelin. Each type of leukodystrophy is the result of a specific genetic defect. Most leukodystrophies are passed from parent to child, though some may develop in people without a family history.