X-linked adrenoleukodystrophy (ALD) is a rare inherited genetic disorder. There are 40 subtypes of leukodytsrophy. X-linked ALD is the most common category. ALD results in degeneration of the:
- Myelin sheath— the fatty insulation covering on nerve fibers in the brain
- Adrenal gland and surrounding adrenal cortex—produces vital hormones
Myelin Sheath Around Nerve Fiber
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There are six subtypes of X-linked ALD:
- Childhood cerebral ALD
- Adolescent ALD
- Adult cerebral ALD
- Adrenal insufficiency-only
- Symptomatic heterozygotes
Last reviewedJune 2014by Kari Kassir, MD
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