Pemphigus is a group of disorders that affects the skin. The attacks cause blisters and burn-like wounds on skin and mucous membranes (like mouth). There are 3 forms of the disease:

  • Pemphigus vulgaris—most common type of pemphigus
  • Pemphigus foliaceus
  • Paraneoplastic pemphigus—most serious type, usually occurs with cancer

Pemphigus is an autoimmune disorder. The immune system attacks healthy skin and mucus membranes. The attack causes the sores on the skin.

It is not clear what causes the immune system to attack normal body tissue. It is likely due to a combination of genetic and environmental factors. For some, medication may be the cause.