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Principal Proposed Natural Treatments
Other Proposed Natural Treatments
Burdock ; Coleus forskohlii ; Combination Cream Containing Mahonia aquifolium; Fish Oil ; Probiotics (Treatment) ; Quercetin ; Red Clover ; Red Vine Leaf and Licorice; Sea Buckthorn ( Hippophae rhamnoides) ; Viola tricolor and Centella asiatica; Zinc
Probably Not Effective Treatments
Oral use of Gamma-linolenic Acid (GLA) from Evening Primrose Oil or Borage Oil
Eczema is an allergic reaction that occurs in the skin. It consists mainly of itchy, inflamed patches on the face, elbows, knees, and wrists. Eczema is most commonly found in infants and young children. Eczema is closely associated with asthma and hay fever. All together, they are called atopy. Atopy tends to run in families.
Medical treatment for eczema consists mainly of antihistamines and topical steroid creams.
Probiotics are health-promoting bacteria. The most famous probiotic is Lactobacillus acidophilus, used to make yogurt. Probiotics are thought to have immune-regulating actions. Use of probiotics during pregnancy and after childbirth may reduce risk of childhood eczema, presumably by, in some unknown fashion, normalizing immune response.
The benefits of probiotics for eczema prevention were seen in a small 2001 study.11Also, in a very large, long-term, double-blind study, 1,223 pregnant women were given either placebo or a probiotic mixture (containing lactobacilli and bifidobacteria) beginning 2-4 weeks before delivery.38Their newborn children then received either probiotics or placebo for 6 months. The results showed that the probiotics mixture markedly reduced incidence of eczema, but not other allergic diseases. A follow-up study of these 1,223 mother-child pairs found that probiotics for mother and infant were not associated with reduced eczema, allergic rhinitis or asthma in children followed through age 5 years.51Another study yielded marginal results,42and a third study found no benefit at all for the prevention of eczema. This latter study actually demonstrated a modestly increased risk of wheezing bronchitis in those infants who took the lactobacilli.47 Finally, researchers in another study concluded that not all probiotics are created equal. In this placebo-controlled study involving pregnant women and their infants, Lactobacillus rhamnosus reduced the incidence of eczema in the children, but a strain of Bifidobacterium animalisdid not.49
Lactobacillus plantarum was effective in reducing the severity of eczema symptoms. The randomized trial included 118 children aged 1-13 years with eczema comparing L. plantarumto placebo for 12 weeks.56
In addition, some but not all double-blind trials have found evidence that infants and children who already have eczema may benefit from the use of probiotics.12,13,20,21,33-34,39,53However, in a careful review of 12 studies involving a total of 781 children researchers concluded that there is no convincing evidence that probiotics can effectively treat eczema.50
If probiotics are beneficial for childhood eczema, they are probably more effective at preventing the condition rather than treating it.54Three reviews of numerous studies cautiously conclude that probiotics may help reduce the risk of eczema in infants and children, particularly in those at high risk and when probiotics are given both to mother (before giving birth) and infant.44,46,48 However, in a double-blind, placebo-controlled study of 231 infants born to women with allergies, giving Lactobacillus acidophilusto the infants failed to reduce their risk of developing eczema.40
For more information, including dosage and safety issues, see the full Probiotics article.
Early exposure of the infant to allergenic substances found in infant formula may play a role in the development of eczema. Breastfeeding might, therefore, help prevent this condition.
A large study lends credence to this theory.8 More than 17,000 women in the Republic of Belarus were enrolled. About half were entered in a program that encouraged them to breastfeed (the "intervention group"), while the other half were enrolled in a different program that did not instigate any particular method of infant feeding (the "control group").
The results showed that women encouraged to breastfeed were much more likely to do so than other women. Furthermore, children of women in the intervention group showed almost a 50% reduction in the incidence of eczema.
Interpreting this study is trickier than it might appear. Technically, it does not prove that breastfeeding reduces risk of eczema. Rather, it shows that counseling to breastfeed reduces risk of eczema. However, the implication is fairly compelling: if you breastfeed your child, he or she is less likely to develop eczema.
Chinese Herbal Medicine
A combination of traditional Chinese herbs has shown promise as a treatment for eczema. This proprietary formula contains Ledebouriella seseloides, Potentilla chinensis, Akebia clematidis, Rehmannia glutinosa, Paeonia lactiflora, Lophatherum gracile, Dictamnus dasycarpus, Tribulus terrestris, Glycyrrhiza uralensis, and Schizonepeta tenuifolia. In paired double-blind, placebo-controlled trials carried out by one research group, the mixture produced significantly better effects than placebo for both adults and children.22,23
Each study enrolled approximately 40 people and used a cross-over design in which all participants received the real treatment and placebo for 8 weeks each. Use of the herbal combination significantly reduced eczema symptoms compared to placebo. However, a subsequent study of similar design performed by a different research group failed to find significant benefit.24 The reason for this discrepancy is not clear.
In a 12 week, double-blind study, a different traditional Chinese herbal formula also failed to prove more effective than placebo for treatment of eczema.41
Asian herbal creams marketed for eczema have often been found to contain high potency corticosteroid drugs that are not listed on the label.28
For more information, including safety issues, see the Traditional Chinese Herbal Medicine article.
Topical creams made from chamomile, licorice, or calendula, alone or in combination, are widely used in Europe to treat eczema. One study of 161 individuals found chamomile cream equally effective as 0.25% hydrocortisone cream for the treatment of eczema.14 However, the report didn't state whether doctors or patients were blinded as to which treatment was which, so it isn't clear how reliable the results may be. (For information on why "blinding" is essential, see Why Does This Database Rely on Double-Blind Studies?
A study by the same authors (also not double-blind), involving 72 individuals with eczema, found somewhat odd results. In this trial, chamomile was not significantly more effective than placebo, but both were better than 0.5% hydrocortisone cream.15 It is difficult to interpret what these results actually mean, but they certainly cannot be taken as proof that chamomile cream is effective.
The herb St. John’s wortis most often used for the treatment of depression. St. John’s wort contains a substance, hypericin, that is thought to have anti-inflammatory properties, making it potentially useful in eczema as well. In a double-blind study, a cream containing St. John’s wort extract was compared against placebo cream in 21 people with mild to moderate eczema symptoms.25 Study participants used real cream on one arm and the placebo cream on the other. The results indicated that use of St. John’s wort cream significantly reduced symptoms.
Another placebo-controlled, double-blind study, enrolling 49 people with eczema, found benefit with a cream containing vitamin B12at a concentration of 0.07%.30 Topical B 12 is thought to work in eczema by affecting local levels of a substance called nitric oxide (NO). A small study of 21 children aged 6 months to 18 years found that topical application of vitamin B12for up to 4 weeks improved skin check scores compared to placebo.52
A double-blind, placebo-controlled study of 88 people with eczema tested a cream containing extracts of Mahonia aquifolium, Viola tricolor, and Centella asiatica.45 The results failed to show benefit overall. A post-hoc (after the fact) analysis noted benefits among those participants who were not tested in the hottest time of the year. However, due to the mathematical laws of statistics, such retroactive evaluations are of limited meaningfulness.
Evening Primrose Oil/GLA
Evening primrose oil, taken orally, has been widely used in Europe for the treatment of eczema. Evening primrose is a rich source of the essential fatty acid gamma-linolenic acid (GLA). Other sources of GLA include borage oil and black currant oil. However, the most recent and best-designed studies have failed to find GLA supplements helpful for eczema.3-6,31More recently, topical application of GLA has been tried.45
A review of all studies reported up to 1989 found that oral use of evening primrose oil reduced the symptoms of eczema after several months of use, with the greatest improvement noticeable in the level of itching.1However, this review has been sharply criticized: it included studies of very poor design, and also, apparently, misinterpreted the results of some of the studies it evaluated.2
Better designed studies published subsequent to this review have not shown promising results. A double-blind, placebo-controlledstudy that followed 58 children with eczema for 16 weeks found no difference in effectiveness between evening primrose oil and placebo.3A 24-week, double-blind study of 160 adults with eczema failed to find benefit with GLA from borage oil,4as did a 12-week study of 151 adults and children.31In addition, GLA from evening primrose either alone or in combination with fish oil failed to provide benefits in a 16-week, double-blind, placebo-controlled study of 102 people with eczema.5A fourth double-blind trial followed 39 people with hand dermatitis for 24 weeks. Evening primrose oil at a dosage of 6 g daily produced no significant improvement as compared to the placebo.6
Only one double-blind trial performed subsequent to the 1989 review found therapeutic benefit with evening primrose oil, but it used very high doses of the supplement and found only marginal benefits.7
The bottom line: At the present time, the balance of the evidence suggests that GLA taken orally is probably not effective for treating eczema.
However, an interesting double-blind study tested the use of undershirts coated with borage oil for treatment of eczema.45 In this 2-week study of 32 children aged 1-10 years old, use of these coated undershirts appeared to reduce eczema symptoms. However, additional higher quality research studies need to be undertaken to establish whether or not this method of delivery really works.
For more information, including dosage and safety issues, see the full GLA article.
Last reviewedJuly 2012by EBSCO CAM Review Board
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.