Urethral syndrome is a set of symptoms from inflammation or irritation of the urethra that are not related to a bacterial or viral infection. The urethra is the tube that carries urine out of the body from the bladder. Urethral syndrome is most common in women.

Female Urethra
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Because there is no evidence of infection, the cause of urethral syndrome is often difficult to determine. Possible causes include:

  • Undetected bacterial or viral infection of the urethra
  • Irritation of the urethra, caused by:
    • Radiation exposure
    • Chemotherapy
    • Spermicidal jellies used during sex
    • Bubble baths
    • Irritating soaps
    • Scents or perfumes
    • Injury to the urethra caused by a blow to the pelvic area
    • Sexual intercourse (especially in women)
    • Urinary irritants, such as caffeine and certain foods
  • In women, irritation of the urethra may be caused by:
    • Feminine hygiene sprays or douches
    • Sanitary napkins
    • Contraceptive gels
    • Condoms