The prickly ash tree has a long history of use in Native American medicine. The bark was used to treat intestinal cramps, dry mouth, muscle and joint pain, toothache, nervous disorders, arthritis, and leg ulcers. The berries were used for circulatory problems such as intermittent claudication and Raynaud’s syndrome.

There are no documented medical uses of prickly ash bark.

In test-tube studies, substances called furanocoumarins in prickly ash have shown anti-fungal properties.1Another prickly ash constituent, chelerythrine, has shown activity against antibiotic-resistant staph bacteria.2 However, it is a long way from studies like these to actual evidence of efficacy. Only double-blind, placebo-controlled studies can actually show that a treatment works, and none have been performed on prickly ash. (For information on why such studies are essential, seeWhy Does This Database Rely on Double-blind Studies?)