Erythema multiforme is a skin condition often associated with an overreaction to an infection or medication. It can affect skin throughout the body. Erythema multiforme has two forms:

  • Erythema multiforme minor—most common, is generally mild and may go away on its own
  • Erythema multiforme major—rare, usually more severe, less likely go away on its own, and can be life threatening

Erythema multiforme is an overreaction of the immune system to a certain trigger. Some erythema multiforme is associated with an infection or certain medications, though the exact trigger is not always known. It is not clear why some people have this reaction.